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Tumor Models in Cancer Research |
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From Book News, Inc.
Modeling tumor behavior using the tumor-bearing animal is the central focus of this collection of 34 studies by specialists working for private corporations and public institutions. The studies are divided into the following topics: transplantable syngeneic rodent tumors; human tumor xenografts; carcinogen-induced tumors; mutant, transgenic, and knockout mouse models; metastasis models; normal tissue response models; disease and target-specific models; and experimental methods. Individual topics include murine models of bone-marrow transplant, the intestine as a model for studying stem-cell behavior, the p53-deficient mouse as a cancer model, cyclin D1 transgenic mouse models, and models for studying the action of topoisomerase-I targeted drugs.Book News, Inc.
Book Info
Lilly Research Laboratories, Indianapolis, IN. Reviews the state-of-the-art of the in vivo tumor models available for cancer research and discusses the use and interpretation of tumor models and endpoints. Covers metastatic models and includes a bibliography for each in vivo tumor model. For researchers. DNLM: Neoplasms, Experimental.
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In Memoriam Preface Contributors Pt. I Introduction 1 Perspective on the History of Tumor Models 3 Pt. II Transplantable Syngeneic Rodent Tumors 2 Murine L1210 and P388 Leukemias 23 3 Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice 41 4 B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model 73 Pt. III Human Tumor Xenografts 5 Xenotransplantation of Human Cell Cultures in Nude Mice 93 6 GFP-Expressing Metastatic-Cancer Mouse Models 99 7 Human Tumor Xenografts and Explants 113 Pt. IV Carcinogen-Induced Tumors: Models of Carcinogenesis and Use for Therapy 8 Hamster Oral Cancer Model 141 9 Mammary Cancer in Rats 173 10 Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies 183 Pt. V Mutant, Transgenic, and Knockout Mouse Models 11 Cancer Models: Manipulating the Transforming Growth Factor-[beta] Pathway in Mice 195 12 Cyclin DI Transgenic Mouse Models 223 13 Mice Expressing the Human Carcinoembryonic Antigen: An Experimental Model of Immunotherapy Directed at a Self, Tumor Antigen 231 14 The p53-Deflicient Mouse as a Cancer Model 247 15 The Utility of Transgenic Mouse Models for Cancer Prevention Research 263 Pt. VI Metastasis Models 16 Metastasis Models: Lungs, Spleen/Liver, Bone, and Brain 277 17 Models for Evaluation of Targeted Therapies of Metastatic Disease 293 Pt. VII Normal Tissue Response Models 18 Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation 323 19 The Intestine as a Model for Studying Stem-Cell Behavior 337 20 SENCAR Mouse-Skin Tumorigenesis Model 359 21 Murine Models of Bone-Marrow Transplant Conditioning 381 22 Anesthetic Considerations for the Study of Murine Tumor Models 407 Pt. VIII Disease and Target-Specific Models 23 Tissue-Isolated Tumors in Mice: Ex Vivo Perfusion of Human Tumor Xenografts 435 24 Human Breast-Cancer Xenografts as Models of the Human Disease 453 25 Animal Models of Melanoma 471 26 Experimental Animal Models for Renal Cell Carcinoma 493 27 Animal Models of Mesothelioma 507 28 SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development 521 29 Models for Studying the Action of Topoisomerase-I Targeted Drugs 541 30 Spontaneous Pet Animal Cancers 565 Pt. IX Experimental Methods and End Points 31 In Vivo Tumor Response End Points 593 32 Tumor-Cell Survival 617 33 Apoptosis in Vivo 633 34 Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function, and Drug Delivery in Tumors 647 Index 673 |
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