From Book News, Inc.

Biological and medical researchers mostly from anglophone countries, but also Brazil, Belgium, and Sweden describe how the advent of microbial genome sequencing and algorithms to compare and annotate genomes has provided information on the fundamentals of pathogenesis and how organisms interact with each other and with their host environment, and promises to identify places where intervention will have a significant positive impact on human health. Within sections on viruses, bacteria, fungi, and protozoa, they discuss such topics as the microarray analysis of human papillomavirus pathogenesis, and using bioinformatics to select antifungal targets in Aspergillus nidulans.Book News, Inc.

Book Info

Johnson and Johnson Pharmaceutical Research and Development, L.L.C., San Diego, CA. Offers specialists an analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics. Covers the genomics of infectious viruses, bacteria, fungi, and protozoa. DNLM: Microbiologic Phenomena--genetics.

Preface
Contributors
1 Antiviral Drug Target Discovery with DNA Microarrays 1
2 Chipping Away at HIV Pathogenesis 13
3 Microarray Analysis of Human Papillomavirus Pathogenesis 25
4 Ribozymes as Gene Therapeutic Agents for HIV/AIDS: A Potential Paradigm Shift 39
5 Genomics and New Technologies Applied to Antibacterial Drug Discovery 53
6 Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines 69
7 Bacterial "Genes-to-Screens" in the Post-Genomic Era 83
8 DNA Microarray Expression Analysis in Antibacterial Drug Discovery 97
9 The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens 97
10 Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development 133
11 Antifungal Target Discovery and Evaluation: Lessons from Saccharomyces cerevisiae 155
12 Antifungal Drug Discovery: Old Drugs, New Tools 167
13 Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era 197
14 Antifungal Target Selection in Aspergillus nidulans: Using Bioinformatics to Make the Difference 215
15 Functional Genomics of Histoplasma capsulatum: Dimorphism and Virulence 231
16 Gene Finding in Coccidioides immitis: Searching for Immunogenic Proteins 247
17 Toxoplasma gondii: A Model for Evolutionary Genomics and Chemotherapy 255
18 The Molecular Biology and Pathogenicity of Entamoeba histolytica 281
Index 303