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Scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation and discuss what impact these advances may have on medicine and science. They examine the biological and immunological hurdles to xenotransplantation, show how the immune system interacts with the xenograft, and lay a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease. Platt works in transplantation biology at the Mayo Clinic.Book News, Inc.

Book Info

Mayo Clinic, Rochester, MN. Provides a base of knowledge for the practitioner, fellow, and student, and those involved in biotechnology and related sciences. Explains the fundamental molecular and cell biology that has been applied in the emerging fields of transplant immunology and xenotransplantation

Preface
Contributors
1 Molecular and Cellular Hurdles to Xenotransplantation 1
2 Pathological Responses to Xenotransplantation 45
3 Natural Xenoreactive Antibodies 57
4 Specificity of Xenoreactive Natural Antibodies 73
5 Biophysical Properties of Xenoreactive Natural Antibodies 87
6 The Origin of Xenoreactive Natural Antibodies 103
7 Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies 119
8 The Complement Barrier to Xenotransplantation 139
9 Defects and Amplification of Costimulation Across the Species 173
10 Antibody-Dependent Effects on Cellular Immunity 199
11 Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation 215
12 Current Applications of Cellular Xenografts 247
Index 265