Abstract
A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

From Book News, Inc.
This work reviews what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, and looks at their potential for optimizing vaccine performance. Chapters on diseases such as mycobacterial infections, lyme arthritis, HIV, and sepsis demonstrate cytokine and chemokine production profiles and discuss the importance of host genetic factors in determining type and magnitude of responses to a microorganism. Kotb is affiliated with the University of Tennessee VA Medical Center. Calandra is affiliated with the Centre Hospital Universitaire Vaudois, Switzerland.Copyright 2004 Book News, Inc., Portland, OR

Book Info
Univ. of Tennessee, Memphis. Text provides a comprehensive review of cytokines and chemokines in immunity and human infectious diseases. Covers bacterial, viral, fungal, and parasitic infections. Includes an evaluation of therapeutic strategies and agents and the role in modulating host responses to pathogens and vaccines. DNLM: Chemokines--immunology.