Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to under-stand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses.

This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest.

Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources.

Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.

Table of contents

Volume 1

Preface

Acknowledgments

About the Authors

PART I: The Science of Virology

1 Foundations

2 The Infectious Cycle



PART II: Molecular Biology

3 Genomes and Genetics

4 Structure

5 Attachment and Entry

6 Synthesis of RNA from RNA Templates

7 Synthesis of RNA from DNA Templates

8 Processing

9 Replication of DNA Genomes

10 Reverse Transcription and Integration

11 Protein Synthesis

12 Intracellular Trafficking

13 Assembly, Release, and Maturation

14 The Infected Cell



Volume 2

1 Infections of Populations: History and Epidemiology

2 Barriers to Infection

3 The Early Host Response: Cell Autonomous and Innate Immunity

4 Adaptive Immunity and the Establishment of Memory

5 Patterns and Pathogenesis

6 Cellular Transformation and Oncogenesis

7 Vaccines

8 Antiviral Drugs

9 Therapeutic Viruses

10 Virus Evolution

11 Emergence

12 Human Immunodeficiency Virus Type I Pathogenesis

13 Unusual Infectious Agents