From Book News, Inc.
Contains papers from a February 1997 conference held in Jerusalem, Israel, detailing basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Describes clinical syndromes, and approaches the clinical management of mucociliary dysfunction using currently available diagnostic and therapeutic techniques. Subjects include genetic determinants of mucociliary system structure and function, ciliary wave activity in cell-cell communication, key physiological processes in ciliary regulation, and possible means of treating irregularities in mucus secretion and clearance. Book News, Inc., Portland, OR

Book Description
Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions discusses the genetic determinants of mucociliary system structure and function explains ciliary wave activity in cell-cell communication elucidates many of the key physiological processes in ciliary regulation reveals possible means of treating irregularities in mucus secretion and clearance improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

BASIC SCIENCE
Dynein Regulation
Molecular Biology of Axonemal Dynein and Its Role in Ciliary Motility,
I. R. Gibbons
Modeling Outer Dynein Arm Activity and Its Relation to the Ciliary Beat Cycle,
Peter Satir, Toshikazu Hamasaki, and Michael Holwill
Ciliary Regulation
Regulation of Outer Arm Dynein Activity via Light Chain Phosphorylation,
Toshikazu Hamasaki, Jason Nielson, and Peter Satir
Inhibitory and Excitatory Neural Regulation of the Mucociliary Transport System,
Donovan B. Yeates
The Nucleoside Diphosphate Kinase and Chloride-Sensitive GTP-Dependent
Phosphorylation in Apical Membrane from Ciliated Airway Cells,
R. Muimo, S. J. Banner, Lindsay Marshall, and Anil Mehta
Regulation of Ciliogenesis and Ciliated Cell Specific Genes,
Lawrence E. Ostrowski, Kaya L. Andrews, Pravin D. Potdar, and Paul Nettesheim
Mucus Transporting Cilia: A Model System for Investigating Calcium
Signaling in Electrically Inexcitable Cells,
Alon Korngreen and Zvi Priel
Intercellular Communication in Mammalian Airway-Ciliated Epithelia, Ellen Roter Dirksen
b2 Agonist Terbutaline Makes the Ciliary Beat Frequency of Freshly
Isolated Human Airway Cells Refractory to Calcium Signaling,
Gordon Honeyman, P. J. Kemp, C. Cobain, D. P. Dhillon, John H. Winter, and Anil Mehta
Ionic Mechanisms in Olfactory Reception: Perspective Through Ion Channels in the Vertebrate Olfactory Cilia, Tadashi Nakamura, Tomo-Oki Satoh, Hyung-Hwan Lee, Hirokatsu Kobayashi, and Satoru Noguchi
Modeling of Ciliary Function
Coupling the Internal Axoneme Mechanics of Cilia and Flagella with External Fluid Dynamics, Robert H. Dillon and Lisa J. Fauci
Metachronal Coordination as the Result of Hydrodynamical Coupling Shay Gueron, Konstantin Levit-Gurevich, Nadav Liron, and Jacob J. Blum
Metachronal Wave, Ciliary Stroke, and Mucus Propulsion, Larisa Gheber and Zvi Priel
Roles of Cilia in Filter Feeding and Mucus Transport, John R. Blake, Michael A. Sleigh, and Nadav Liron
Basic Aspect of Mucus
Digital Microrheometry, John Hamilton
Regulation of Differentiation and Mucin Secretion in Tracheobronchial Epithelial Cell Cultures, Paul Nettesheim, K. Guzman, Ja Seok Koo, J.-Y. Yoon, and T. Gray
Intracellular Regulation of Mucin Secretion in Airway Epithelial Cells In Vitro, Bernard M. Fischer, Chengming Li, Hongfei Li, Nonghoon Choe, David T. Wright, Lori G. Rochelle, and Kenneth B. Adler
Cellular Basis for the Purinergic Regulation of Mucin Secretion in the Airways, C. William Davis, Lubna H. Abdullah, and Richard C. Boucher
Polymer Biophysics of Mucus in Cystic Fibrosis, Pedro Verdugo
Evolution of the Frog Palate Model for Mucociliary Clearance-1970-1997, Malcolm King and Eliane Fest
Airway Mucociliary Epithelium Injury and Repair, Edith Puchelle, Anne-Laure Herard, and Jean-Marie Zahm
CLINICAL PRACTICE
Mucociliary Clearance in Various Septal Deformities
Septal Deformities Can Influence the Mucociliary Transport Impairment of the Middle Turbinate Mucosa, Ranko Mladina, Damir Milicic, and Davorin Djanic
Aspects of Mucociliary Flow and Mechanics in Nasal Cavity and Sinuses, Elina Toskala
Clinical Studies in Human Tubal Structures
Clearance Function of the Eustacian Tube: What We Know, What We Don't Know, Charles D. Bluestone and Cuneyt M. Alper
Clinical Significance of Tubotympanal Mucociliary Clearance in Otitis Media with Effusion,
Kazuhiko Takeuchi, Yuichi Majima, Keisuke Hirata, and Yasuo Sakakura
Mucociliary Function of Respiratory Epithelium-Human and Animal Studies
Effects of Urban Air Pollution on Mucociliary Clearance, Mariangela Macchione, Gyrgy Miklos Bohm, and Paulo Hilario N. Saldiva
Bridging the Gap Between Airway Ion Transport and Mucociliary Clearance
Improved Mucociliary Clearance Following Nebulization with Hypertonic Saline in Adults with Cystic Fibrosis, Michael Robinson, Ariane Hemming, Jeff A. Regnis, Dale L. Bailey, Malcolm King, Wei Feng, George Bautovich, and Peter Bye
Ciliary Transportability of Sputum is Governed by Its Osmolality, Peter John Wills, Roderick L. Hall, W. M. Chan, and Peter J. Cole
Mucociliary Clearance in the Guinea Pig is Increased by Ouabain (i.v.) and by Hypertonic Saline (14.4%) Aerosol, B. Ben Newton and Roderick L. Hall
Interventions that Increase Mucociliary Clearance in Asthmatic and Healthy Subjects, Evangelia Daviskas and Sandra D. Anderson
Mucociliary and Cough Clearance: Role of Ion Transport and the P2Y2 Receptor-Mediated System, Michael R. Knowles, Peadar G. Noone, William D. Bennett, and Richard. C. Boucher
Laboratory and Clinical Studies of Mucus
Surface Properties of Respiratory Secretions: Relationship with Mucus Transport, Bruce K. Rubin
Cellular Components of Airway Secretions: Recruitment and Regulation, Stephen Rennard
DNA and Actin Filament Ultrastructure in Cystic Fibrosis Sputum, Robert P. Tomkiewicz, Chikako Kishioka, John Freeman, and Bruce K. Rubin
Airway Bacteria and Mucus Production
Is Bacterial Colonization of the Airways Relevant?, Adam Wanner, Matthias Salath, Kenji Kobayashi, William M. Abraham, Zsuzsanna Seybold, and Jolanta T. Jackowski
Mucin Synthesis is Upregulated at the Transcriptional Level by P. aeruginosa LPS, Carol B. Basbaum and Jian-Dong Li
Tissue Distribution of Secretory Mucins and Alterations of Mucin Gene Expression in Chronic H. pylori Infection of the Stomach, Samuel B. Ho
Effect of Pseudomonas aeruginosa Alginate on Airway Mucus Secretion, Chikako Kishioka, Robert P. Tomkiewicz, Daniel J. Hassett, and Bruce K. Rubin
Medical Moduation of Mucus
Analysis of Mucociliary Dysfunction, Yasuo Sakakura and Yuichi Majima
Effects of Mucokinetic Agents on Nasal Mucus, Yuichi Majima
Pharmacological Management of Mucus Retention Based on a Taxonomy of Mucoactive Medications, Bruce K. Rubin
Experimental Models for Mucus Drug Research, Takeshi Miyata and Hirofumi Kai
Definition and Diagnosis of Primary and Secondary Mucociliary Disfunction
Ciliary Beat Frequency, Ultrastructural Abnormalities, and Mucus Clearance in Primary Ciliary Dyskinesia (PCD), Michael T. Newhouse
Diagnosis of Primary Ciliary Dyskinesia, Jonathan Rutland, Lucy Morgan, Karen Waters, Peter van Asperen, and Robert U. de Iongh
Mucociliary Clearance in Health and Disease: Qualitative and Quantitative Analysis, Toyoharu Isawa
Human Ciliated Epithelium In Vitro: Mechanisms of Injury and Protection, Charles Feldman, Ronald Anderson, Andrew Rutman, Peter Cole, and Robert Wilson
Biochemical and Pharmacological Regulation of Mucociliary Activity
Regulation of Mucociliary Activity in the Upper Airways by Nitric Oxide: Clinical Implications,
Sven Lindberg, Birgitta Carlen, Anders Cervin, Catarina Cramnert, and Thomas Runer
Ciliary Stimulation by Extracellular ATP in Frog Esophagus and Palate Epithelium, Alex Braiman and Zvi Priel
The Messianic Relationship Between Inspiration and Expectoration, Irwin Ziment
Mucociliary Clearance in Paranasal Sinuses
An Approach to Imaging Interpretation in Paranasal Sinus Disease, Arnold M. Noyek, Edward Earl Kassel, Ian James Witterick, Dan M. Fliss, Yehudah Roth, and George Wortzman
Miscellaneous Ciliary Function
Chronic Sinusitis in Relation to the Lower Airway, Saul Frenkiel and Chantal Giguere
Immune Responses in the Chronic Inflammatory Process Within the Paranasal Sinus Mucosa, Erin Daniel Wright, Saul Frenkiel, and Qutayba Hamid
Character of Bronchopulmonary Changes in Patients with Primary Ciliary Dyskinesia, Jacek Pawlik, Jerzy Zebrak, Michal Witt, and Andrzej Pogorzelski
Diagnosis, Treatment, and Prevention of Mucociliary Dysfunction
Genetic Counselling of Adults with Primary Ciliary Dyskinesia or Cystic Fibrosis, Hans-Dieter Rott
Preliminary Exclusion of Chromosome 7 as a Potential Location of a Gene for Primary Ciliary Dyskinesia, Michal Witt, Elizabeth Gillanders, Shengbiao Wang, Diana Freas-Lutz, Cui-E Sun, Jerzy Zebrak, Jacek Pawlik, Ewa Rutkiewicz, and Scott R. Diehl
Bend Shapes and Molecular Mechanisms of Flagella, Michael Holwil