The bestselling introduction to bioinformatics and genomics - now in its third edition

　Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

　This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

　　　ㆍ　Extensive revisions and a slight reorder of chapters for a more effective organization
　　　ㆍ　A brand new chapter on next-generation sequencing
　　　ㆍ　An expanded companion website, also updated as and when new information becomes available
　　　ㆍ　Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities

　The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

　Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Part　I　Analyzing DNA RNA and Protein Sequences
　　　　-　1 Introduction 3
　　　　-　2 Access to Sequence Data and Related Information 19
　　　　-　3 Pairwise Sequence Alignment 69
　　　　-　4 Basic Local Alignment Search Tool (BLAST) 121
　　　　-　5 Advanced Database Searching 167
　　　　-　6 Multiple Sequence Alignment 205
　　　　-　7 Molecular Phylogeny and Evolution 245

Part　II　Genomewide Analysis of DNA RNA and Protein
　　　　-　8 DNA: The Eukaryotic Chromosome 307
　　　　-　9 Analysis of Next-Generation Sequence Data 377
　　　　-　10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433
　　　　-　11 Gene Expression: Microarray and RNA-seq Data Analysis 479
　　　　-　12 Protein Analysis and Proteomics 539
　　　　-　13 Protein Structure 589
　　　　-　14 Functional Genomics 635

Part　III　Genome Analysis
　　　　-　15 Genomes Across the Tree of Life 699
　　　　-　16 Completed Genomes: Viruses 755
　　　　-　17 Completed Genomes: Bacteria and Archaea 797
　　　　-　18 Eukaryotic Genomes: Fungi 847
　　　　-　19 Eukaryotic Genomes: From Parasites to Primates 887
　　　　-　20 Human Genome 957
　　　　-　21 Human Disease 1011

GLOSSARY 1075
Self-Test Quiz: Solutions 1103
Author Index 1105
Subject Index 1109