Easy-to-apply set of principles for selecting the right antibiotic
Antibiotic Basics for Clinicians, Second Edition, shows you how to apply your knowledge of pharmacology and microbiology in order to select the appropriate antibiotic. Rather than rely on rote memorization, you’ll learn the underlying rationale for treatment of common infectious diseases and pathogens. The text focuses on antibacterial agents, examining individual antibiotics and antibiotic classes as well as definitive and empiric therapies—providing a framework for prescription and clinical preparation for students training to be physicians, nurse practitioners, physician assistants, pharmacologists, or medical technologists. Clinicians also rely on Antibiotic Basics for quick reference or review.

The Second Edition includes current research and new approaches to emerging resistant organisms such as community-acquired, methicillin-resistant Staphylococcus aureus and Klebsiella pneumoniae carbapenemase-producing bacteria. In addition, the book has been updated to reflect changes in treatment guidelines, including new guidelines for Clostridium difficile colitis and urinary tract infections.

Special features help you “think like a clinician”:

Illustrations help you understand how antibiotics fight against bacterial infections.
Mnemonics throughout the text make it easier to remember which antibiotics are prescribed for specific pathogens.
Searchable online version of the text takes you to the content you need from any web-enabled device.
Case studies demonstrate how the principles set forth in the text are applied in clinical practice.
Questions and answers improve your ability to choose the right antibacterial agent.
Appendices include dosing for adults and children, use of antibacterial agents in pregnancy, and treatment of bioterrorism agents.

Preface

I. Bacterial Basics
1. Cell Envelope
2. Protein Production
3. Replication
4. Measuring Susceptibility to Antibiotics

II. Antibacterial Agents
5. Antibiotics That Target the Cell Envelope
β-Lactam Antibiotics
Glycopeptides
Daptomycin
Colistin
6. Antibiotics That Block Protein Production
Rifamycins
Aminoglycosides
Macrolides and Ketolides
Tetracyclines and Glycylcyclines
Chloramphenicol
Clindamycin
Streptogramins
Linezolid
Nitrofurantoin
7. Antibiotics That Target DNA and Replication
Sulfa Drugs
Quinolones
Metronidazole
8. Antimycobacterial Agents
9. Summary of Antibacterial Agents

III. Definitive Therapy
10. Gram-Positive Bacteria
Staphylococci
Pneumococci
Other Streptococci
Enterococci
Other Gram-Positive Bacteria
11. Gram-Negative Bacteria
Enterobacteriaceae
Pseudomonas
Neisseria
Curved Gram-Negative Bacilli
Other Gram-Negative Bacteria
12. Anaerobic Bacteria
Clostridia
Anaerobic Gram-Negative Bacilli
13. Atypical Bacteria
Chlamydia
Mycoplasma
Legionella
Francisella tularensis
Rickettsia
14. Spirochetes
Treponema pallidum
Borrelia burgdorferi
Leptospira interrogans
15. Mycobacteria
Mycobacterium tuberculosis
Mycobacterium avium Complex
Mycobacterium leprae
IV. Empiric Therapy
16. Pneumonia
17. Urinary Tract Infections
18. Pelvic Inflammatory Disease
19. Meningitis
20. Cellulitis
21. Otitis Media
22. Infective Endocarditis
23. Intravascular-Related Catheter Infections
24. Intra-Abdominal Infections
V. Clinical Cases
VI. Review Questions and Answers
Appendices
1. Dosing of Antibacterial Agents in Adults
2. Dosing of Antibacterial Agents in Children
3. Dosing of Antibacterial Agents in Adults With Renal Insufficiency
4. Antibacterial Agents in Pregnancy
5. Generic and Trade Names of Commonly Used Antibacterial Agents
6. Treatment of Infections Caused by Bacterial Agents of Bioterrorism
7. Medical References
8. Literary References
9. Answers to Chapter Questions
Index