Clear, concise, and in full color, Harper’s Illustrated Biochemistry is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of disease. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper’s offers an organization and careful balance of detail and brevity not found in any other text on the subject.





Following two introductory chapters, the text is divided into six main sections:
Section I addresses the structures and functions of proteins and enzymes.
Section II explains how various cellular reactions utilize or release energy and traces the pathways by which carbohydrates and lipids are synthesized and degraded.
Section III covers the amino acids, their metabolic fates, certain features of protein catabolism, and the biochemistry of the porphyrins and bile pigments.
Section IV describes the structure and function of nucleotides and nucleic acids, DNA replication and repair, RNA synthesis and modification, protein synthesis, the principles of recombinant DNA technology, and new understanding of how gene expression is regulated. Section V deals with aspects of extracellular and intracellular communication.
Section VI includes fifteen special topics, ranging from nutrition, digestion and absorption to the biochemistry of aging





New to this edition:








New chapters on Aging, Cancer, and Clinical Chemistry



Every chapter has been updated to reflect the latest advances in knowledge and technology



Each chapter now begins with a statement of objectives, followed by a brief discussion of the biomedical importance of topics discussed within the chapter



250 multiple-choice questions to test your knowledge and comprehension



Increased number of tables that encapsulate important information, such as vitamin and mineral requirements

Section 1: Structures and Functions of Proteins and Enzymes


1. Biochemistry & Medicine

2. Water & pH 7

3. Amino Acids & Peptides

4. Proteins:Determination of Primary Structure

5. Proteins: Higher Orders of Structure

6. Proteins: Myoglobin & hemoglobin

7. Enzymes:Mechanism of Action

8. Emzymes: Kinetics

9. Enzumes: regulation of Activities

10. Bioinformatics & Computational Biology

Section 2: Bioenergetics and the Metabolism of Carbohydrates and Lipids


11. Bioenergetics: The Role of ATP

12. Biologic Oxidation

14. Carbohydrates of Physiologic Significance

15. Lipds of Physiologic Significance

16. Overview of Metabolism & the Provision of Metabolic Fuels

17. The Citric Acid Cycle: The Catabolism of Acetyl-CoA

18. Glycolysis & the Oxidation of Pyruvate

19. Metabolism of Glycogen

20. Gluconeogenesis & the Control of Blood Glucose

21. The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism

22. Oxidation of Fatty Acids: Ketogenesis

23. Biosynthesis of Fatty Acids & Eicosanoids

24. Metabolism of Acylglycerols & Sphingolipids

25. Lipid Transport & Storage

26. Cholesterol Synthesis, Transport, & Excretion

Section 3: Metabolism of Proteins and Amino Acids


27. Biosynthesis of the Nutritionally Nonessential Amino Acids

28. Catabolism of Proteins & of Amino Acid Nitrogen

29. Catabolism of te Carbon Skeletons of Amino Acids

30. Conversion of Amino Acids to Speicalized Products

31. Pophyrins & Bile Pigments

Section 4: Structure, Function and Replication of Infomraitonal Macromolecules


32. Nucleotides

33. Metabolism of Purine & Pyrimidine Nucleotides

34. Nucleic Acid Structure & Function

35. DNA Organization, Replication, & Repair

36. RNA Synthesis, Processing, & Modification

37. Protein Synthesis & The Genetic Code

38. Regulation of Gene Expression

39. Molecular Genetics, Recombinant DNA, & Genomic Technology

Section 5: Biochemistry of Extracellular and Intracullular Communication


40. Membranes: Structure & Function

41. The diversity of the Endocrine System

42. Hormone Action & Signal Transduction

Section 6: Special Topics (will highlight the 16 cases)


43. Nuturition, Digestion & Absorption

44. Micronutrients: Vitamins & Minerals

45. Free Radicals and Antioxidant Nutrients

46. Intracellular Traffic & Sorting of Proteins

47. Glycoproteins

48. The Extracellular Matrix

49. Muscle & the Cytoskeleton

50. Plasma Proteins & Immunoglobulins

51. Hemostasis & Thrombosis

52. Red & White Blood Cells

53. Metabolism of Xenobiotics

54. The Biochemistry of Aging

55. Cancer: An Overview

56. Clinical Biochemistry

57. Biochemical Case Histories

Appendix

The Answer Bank

Index