해외 및 국내 입고 사항에 따라 3~4주 정도 소요될 수 있습니다.
해외주문도서는 고객님의 요청에 의해 주문하는 상품으로, 취소, 반품이 불가합니다.


Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.

Part I The Problem and Available Resources
1 Introduction to Evidence-Based Pathology
and Laboratory Medicine ........................................................... 3
Alberto M. Marchevsky and Mark R. Wick
2 Evidence-Based Pathology: A Stable Set of Principles
for a Rapidly Evolving Specialty................................................. 19
José Costa and Sarah Whitaker
3 What Is Best Evidence in Pathology?.......................................... 27
Peter J. Saunders and Christopher N. Otis
4 Biostatistics 101............................................................................. 41
Robin T. Vollmer
5 Prognostication and Prediction in Anatomic Pathology:
Carcinoma of the Breast as an Illustrative Model..................... 61
Mark R. Wick, Paul E. Swanson, and Alberto M. Marchevsky
6 Principles of Classification and Diagnosis in Anatomic
Pathology and the Inevitability of Problem Cases..................... 95
Michael Hendrickson
7 Evaluating Oncopathological Studies:
The Need to Evaluate the Internal and External
Validity of Study Results.............................................................. 121
Michael Hendrickson and Bonnie Balzer
8 Power Analysis and Sample Sizes in Pathology Research......... 141
Robin T. Vollmer
9 Meta-Analysis: A Statistical Method to Integrate
Information Provided by Different Studies................................ 149
Eleftherios C. Vamvakas
10 Decision Analysis and Decision Support Systems
in Anatomic Pathology................................................................. 173
Michael Hendrickson and Bonnie Balzer
Part II Solutions Offered by Evidence-Based Pathology
and Laboratory Medicine
11 Evidence-Based Approach to Evaluate Information
Published in the Pathology Literature and Integrate
It with Personal Experience......................................................... 189
Alberto M. Marchevsky and Mark R. Wick
12 Evidence-Based Cell Pathology Revisited:
A Personal View............................................................................ 203
Kenneth A. Fleming
13 Development of Evidence-Based Diagnostic Criteria
and Prognostic/Predictive Models: Experience
at Cedars Sinai Medical Center................................................... 213
Alberto M. Marchevsky and Ruta Gupta
14 Evaluation and Reduction of Diagnostic Errors
in Pathology Using an Evidence-Based Approach..................... 235
Raouf E. Nakhleh
15 Meta-Analysis 101 for Pathologists............................................. 245
Ruta Gupta and Alberto M. Marchevsky
16 Evidence-Based Practices in Applied
Immunohistochemistry: Dilemmas Caused
by Cross-Purposes......................................................................... 261
Mark R. Wick, Paul E. Swanson, and Alberto M. Marchevsky
17 Evidence-Based Pathology and Laboratory Medicine
in the Molecular Pathology Era: Transition of Tests
from the Research Bench into Practice....................................... 297
Jia-Perng Jennifer Wei and Wayne W. Grody
18 The Use of Decision Analysis Tools for the Selection
of Clinical Laboratory Tests: Developing Diagnostic
and Forecasting Models Using Laboratory Evidence................ 305
Ji Yeon Kim, Elizabeth M. Van Cott,
and Kent B. Lewandrowski
19 Implementation and Benefits of Computerized
Physician Order Entry and Evidence-Based
Clinical Decision Support Systems.............................................. 323
Stacy E.F. Melanson, Aileen P. Morrison, David W. Bates,
and Milenko J. Tanasijevic
20 Evidence-Based Pathology and Tort Law:
How Do They Compare?.............................................................. 337
Mark R. Wick and Elliott Foucar
Index....................................................................................................... 349