In this second volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques, and controversial issues in reproductive medicine. This volume includes discussion of cutting-edge topics such as epigenetics, proteomics, and the role of the environment in fertility, as well as insightful evidence-based discussion of common clinical procedures. It is the cumulative effort of a preeminent panel of experts presenting each chapter in a clear and well-balanced manner. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all those working to help couples resolve their infertility.

Part I Female Infertility
1 Autoimmunity and Female Infertility: Fact vs. Fiction............ 3
Lawrence N. Odom, Amy M. Cline, and William H. Kutteh
2 Minimal Stimulation IVF............................................................ 11
Ahmad O. Hammoud and Mark Gibson
3 Current Understanding of Anti-Müllerian Hormone.............. 19
Dimitrios G. Goulis, Marina A. Dimitraki,
and Basil C. Tarlatzis
4 The Role of Obesity in Reproduction......................................... 35
Barbara Luke
5 Endometrial Receptivity in Natural and Controlled
Ovarian-Stimulated Cycles......................................................... 43
José A. Horcajadas, José A. Martínez-Conejero,
and Carlos Simón
6 Current Understanding of Mullerian-Inhibiting
Substance...................................................................................... 57
Antonio La Marca, Giovanna Sighinolfi,
and Annibale Volpe
7 Evidence-Based Use of Progesterone During IVF.................... 79
Elena H. Yanushpolsky
8 Monozygotic Twinning and Perinatal Outcomes...................... 91
Kenneth J. Moise Jr. and Ramesh Papanna
9 Multiple Pregnancy Vanishing Twin Syndrome........................ 103
Gabriel de la Fuente, Jose Manuel Puente,
Juan A. García-Velasco, and Antonio Pellicer
Part II Male Infertility
10 The Effect of Cancer Therapies on Sperm:
Current Guidelines...................................................................... 117
Akanksha Mehta and Mark Sigman
11 Environmental Insults on Spermatogenesis............................... 133
Stefan S. du Plessis and Ashok Agarwal
12 Sperm DNA Damage: Causes and Guidelines
for Current Clinical Practice...................................................... 155
Aleksander Giwercman, Marcello Spanò, and Mona Bungum
13 The Emerging Role of the Sperm Epigenome
and its Potential Role in Development....................................... 181
Sue Hammoud and Douglas T. Carrell
Part III Assisted Reproduction Techniques
14 ART and Epigenetic Disorders:
Should We Be Concerned?.......................................................... 197
Christopher N. Herndon and Paolo F. Rinaudo
15 Novel Approaches of Sperm Selection for ART:
The Role of Objective Biochemical Markers of Nuclear
and Cytoplasmic Integrity and Sperm Function...................... 211
Gabor Huszar and Denny Sakkas
16 The Role of the Oocyte in Remodeling of Male
Chromatin and DNA Repair: Are Events During
the Zygotic Cell Cycle of Relevance to ART?............................ 227
Liliana Ramos and Peter de Boer
17 Proteomic/Metabolomic Analysis of Embryos:
Current Status for Use in ART................................................... 245
Mandy G. Katz-Jaffe and Susanna McReynolds
18 Ultrasound-Guided Embryo Transfer....................................... 255
Robert L. Gustofson and William B. Schoolcraft
Part IV Evolving Controversies in Contemporary
Reproductive Medicine
19 IMSI as a Valuable Tool for Sperm Selection
During ART.................................................................................. 263
Monica Antinori, Pierre Vanderzwalmen, and Yona Barak
20 Thoughts on IMSI........................................................................ 277
Gianpiero D. Palermo, Jennifer C.Y. Hu, Laura Rienzi,
Roberta Maggiulli, Takumi Takeuchi, Atsumi Yoshida,
Atsushi Tanaka, Hiroshi Kusunoki, Seiji Watanabe,
Queenie V. Neri, and Zev Rosenwaks
Index...................................................................................................... 291